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It modulates the expression of more than 4,000 human genes by Broad Institute Connectivity Map analysis, including 84 cancer-suppressing or growth-inhibitory genes, per the Pickart 2018 review in International Journal of Molecular Sciences [10]

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This result may be due to the low percentage of functional thyroid tissue in children with cretinism in which T4 is converted to active T3 at the periphery in the presence of Se supplementation only

Neuroscience, 284, 872887