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8 It was shown that in TP53 -mutated myelodysplastic syndromes (MDS) and AML, APR-246 can reactivate the p53 pathway and induce an apoptotic transcriptional program, with synergistic effects of APR-246 and azacytidine

Total sperm motility Thirty-six studies with a total of 4,452 infertile patients (2,516 AOX-treated patients and 1,936 placebo-treated or untreated controls) were included in the analysis of total sperm motility [27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 39, 41, 44, 45, 46, 47, 48, 50, 51, 52, 53, 54, 55, 56, 58, 59, 60, 61, 62, 64, 66, 67, 69, 70, 71]