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Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

Despite these therapies not being initially designed to trigger cellular senescence, it was discovered as early as 1998 that cisplatin could induce cellular senescence in head and neck cancer cells [53]

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To test the involvement of NRF2, we bred the Gclc f/f mouse strain with the Nrf2 f/f mouse strain 57,58 and induced a liver-specific double deletion with the AAV-TBG-Cre virus (hereafter referred to as L-DKO) (Fig