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Although both the PERK-eIF2-ATF4 and ATF6 branches of the UPR have been implicated in the regulation of ferroptosis with diverse cellular context and inducing agents 48,49,50,51,52,53,54,55,56,57,58,59,60 , we found that when the expression of the key transcription factors of the three UPR branches, XBP1, ATF4 and ATF6 was inhibited individually in MDA-MB-231 cells, ferroptosis induction by erastin treatment was not affected (Fig