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Both should be reconstituted with bacteriostatic water, refrigerated at 2-8C, and used within 28 days

No study examined tolerance or dependence with extended use, and no study followed a repeated-dosing cohort beyond a few months

A secondary analysis of a randomized clinical trial further supports these concerns, showing that liraglutide treatment alone significantly reduced hip and lumbar spine bone mineral density (BMD) compared with exercise or placebo