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The concern would be, the genetic change would be permanent so if there is over-expression which may change with various states weight loss, illness, aging, hormonal changes it could cause problems from over-expression with no way to reverse, except remove the pancreas or treated muscle, Kohn said in an email

But this deterioration will most likely be more than offset by Rybelsus going forward

Additionally, ongoing studies are exploring the drugs potential benefits beyond glucose control, including weight management and cardiovascular health, which may further solidify its position in diabetes therapy

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Oral semaglutide represents a significant advancement in diabetes management, merging efficacy with patient convenience