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NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (TLR4-NF-B and STAT3-IL-1 pathways) linked to atherosclerosis, heart failure, and coronary heart disease

Patient support There are several organisations that patients can be signposted to: Acknowledgements The authors would like to thank Shiva T Radhakrishnan, clinical research fellow (IBD), Imperial College Healthcare NHS Trust, for his support and guidance in writing this article

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