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Kalmbacher Are you ready to tackle those stubborn fat areas and achieve your weight loss goals

The first head-to-head clinical trial (SURMOUNT-5, published in the New England Journal of Medicine in 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks compared to 13.7% for semaglutide approximately 47% greater relative weight loss

The medication is fast tracked for approval, having received an FDA priority review voucher in November 2025

As you rehydrate, you may retain water, leading to a temporary increase in weight

Because these medications slow digestion and can cause constipationa known trigger for diverticular flarespatients must prioritize hydration and bowel regularity to minimize risks