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Most people tolerate them incredibly well, and when side effects do pop up, they are usually pretty mild

Lentz et al, 1996) (also see additional references cited in Durand et al, 1997a)

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There is no official contraindication or direct drug interaction between caffeine and semaglutide (marketed as Ozempic, Wegovy, and Rybelsus) listed in the FDA prescribing information

Glucagon-like peptide-1 receptor (GLP-1) agonists are an effective treatment for controlling blood glucose levels in people with type 2 diabetes, particularly those who do not respond, or stop responding to, first-line treatments, such as metformin