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They are a visible marker of cumulative UV damage to the lip tissue
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The underlying mechanisms involve maladaptive auditory-limbic network connectivity and dysregulation of neuro-immune interactions, where astrocytes play a significant role in both neural responses to inflammation and the plasticity regulation implicated in tinnitus pathophysiology (Perin and Pizzala, 2024)
Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, et al