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Statements Author contributions LS: Conceptualization, Investigation, Methodology, Writing original draft, Writing review & editing

examined the administration of a commercial oral supplement with hydrolyzed fish cartilage on skin attributes in a double-blind, placebo-controlled clinical study in 2021 from Brazil [35]

After administration of M2-EVs into the joint of a CIA mouse model, the STMs polarization was significantly shifted from M1 to M2 phenotype in decreased joint swelling, arthritic index score and synovial inflammation, with corresponding reductions in bone erosion and articular cartilage damage (Kim et al., 2022a)

- Attachment of mucous membranes through oral dissolution film