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32 Zinc acts as a cofactor for enzymes of the antioxidant system, and inhibits the enzyme, nicotinamide adenine dinucleotide phosphate oxidase, a prooxidant enzyme, and induces metallothionein synthesis, which is important in the reduction of hydroxyl radicals

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Moreover, together with MZB-related signature transcripts such as Cr2 and Ighm , Gclc was also upregulated in Gclc fl/fl MZB compared to FoB (Fig