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Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2

(Source 1) However, research shows that in cases of dysbiosis (microbiome imbalances) and endotoxemia, a higher intake of vitamin C helps to restore gut-liver functions

2 Glutathione deficiencies are common as it can be depleted due to stress, pollutants, aging, and chronic diseases

However, the antioxidant activity of vitamin C has been observed to mitigate this mechanism in an in vitro study (Alber et al., 2021)