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Decreased activity of complexes I and II is closely associated with reduced ATP production in cardiomyocytes of male obese rats with IR (117), and the inhibition of cytochrome c oxidase and complex IV deteriorates dysfunctional mitochondria and decreases ATP levels (118)

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Importantly, the astrocytic clearance of -synuclein by chaperones, like Hsp70, may confer additional neuroprotection to dopaminergic neurons [6,114]

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You can check out issues further by assessing for increased toxicity or altered amino acid levels

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