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Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition

Abstract The discovery of intrinsically disordered proteins (IDPs) (and, therefore, the establishment of the field of protein intrinsic disorder) was initially driven by low-resolution techniques, which overturned the established lock-and-key paradigm of structural biology by showing that some proteins exist as a dynamic conformational ensemble rather than a single fixed structure