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Procedures such as gastric bypass or sleeve gastrectomy have demonstrated significant long-term weight loss and improvement in obesity-related comorbidities, though patients require lifelong monitoring including thyroid function assessment, as malabsorption may affect levothyroxine requirements

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A recent meta-analysis using a sample of 774 patents from multiple studies provides evidence that PEA is effective in reducing chronic pain and enhancing quality of life (Lang-Illievich et al., 2023)