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Gastroparesis and severe GI motility problems on tirzepatide In December 2025, the FDA updated both the Mounjaro and Zepbound prescribing information to add a specific warning about severe gastroparesis (Section 5.6): tirzepatide is not recommended for people with pre-existing severe gastroparesis

Special care may be needed

In numerous published studies, both PLX3397 and PLX5622 are commonly administered via ad libitum feeding, typically mixed into a standard AIN-76A rodent diet

If your phone has a timer function, set it after each injection

Each format has different bioavailability profiles, so dosing does not translate directly between formats