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Patients were allowed, but not required, to continue concomitant therapy with one DMARD during the trial

They found that the women most likely to have palpitations had them with the same frequency from early perimenopause through early post-menopause

In experiments in mice and in samples of human skin, when the researchers used drugs to target these pathways, they were able to reactivate mature melanocytes and pigmentation-related genes and reverse many features of the dormant cells