At the beginning of the study, all four groups of prediabetic subjects were well over the diagnostic threshold of 100mg/dL
If it has spread to distant organs, its classified as stage IV, which is the most advanced stage
NASH/MASH Studies: Phase 2 trials have evaluated the compound in non-alcoholic fatty liver disease, with reductions in liver fat observed
Adipose tissue in obesity releases proinflammatory cytokines such as tumor necrosis factor (TNF), interleukin6 (IL6) and monocyte chemoattractant protein1 (MCP1), while Kupffer cells and infiltrating macrophages in the liver amplify this inflammatory milieu, contributing to hepatocellular injury and fibrosis [26, 27]
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