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The Connectivity Map approach compares the gene-expression signature a compound induces in cultured cells against a reference database of signatures, inferring which pathological patterns the compound might counteract

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Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1alpha activation

specifically, it is uncertain whether VD deficiency is a trigger for AITD or if thyroid dysfunction leads to lower VD levels (23)