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The fact that nrc2 , a mutant affected in GSH2, also exhibited greater sensitivity in its response to AITC confirmed that the root length phenotype was due to the impairment in the glutathione biosynthetic pathway, irrespective of whether GSH1 or GSH2 carried the mutation

Simultaneously, LPS significantly inhibits the expression of hepatic SIRT1 and FOXA2, which downregulates the NFE2L2/HMOX1 antioxidant signaling axis, diminishes the activity of key antioxidant enzymes (e.g., CAT, SOD, and GPX1), and upregulates autophagy-related proteins such as MAP1LC3-II and ATG5 171

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Semaglutide will not show up on a drug screen, but it will change several markers on a metabolic panel