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Melanotan 2 at a Glance Melanotan 2 (alpha-MSH Analog) Type: Synthetic analog of alpha-MSH | Primary Target: MC1R (melanocortin 1 receptor) | Secondary Targets: MC3R, MC4R, MC5R | Primary Effect: Skin darkening (eumelanin production) | Secondary Effects: Sexual arousal, appetite suppression | Route: Subcutaneous injection | FDA Status: Not approved | Related: PT-141 (bremelanotide), derived from MT-2 research MT-2 was originally developed at the University of Arizona in the 1990s as a potential preventive treatment for skin cancer

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Molecular and Cellular Endocrinology, 464, 6574

Adjustments in concomitant anti-diabetic treatment may be needed

Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months