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Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the step 3 randomized clinical trial
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Thats because exendin-4 was close enough in its amino-acid sequence to provide the same effects as GLP-1, yet different enough that the same enzymes that broke down GLP-1 so quickly didnt have the same effect
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