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Start gradually if you're not currently active, perhaps with 10-minute walks after meals, progressively increasing duration and intensity
Despite the controversies about the expression of GLP-1R in vascular smooth muscle and endothelial cells, studies have shown that GLP-1RAs have anti-proliferative effects on these cells, and also reduced oxidative stress and increased the production of nitric oxide (NO) (137, 138)
This is of significant interest for studies on cellular senescence and the cellular response to genotoxic stress (e.g., UV radiation in keratinocyte cultures)
(Source: PMC / JCI, 2026) Mental health monitoring: If you experience new or worsening depression, anxiety, or thoughts of self-harm while on or after stopping a GLP-1, contact your clinician promptly
