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Eprotirome advanced to phase III for dyslipidemia but was withdrawn after preclinical studies revealed unexpected toxicities in animal models (168)

This urgency is a common early symptom and can be quite uncomfortable

CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells

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However, the regulatory mechanisms of these molecules are still unclear, making it difficult to precisely regulate mitophagy at specific targets in practical situations