how long can semaglutide be out of the refrigerator Is Your Safe? Storage Tips You Need to Know! I Accidentally Took Expired Semaglutide:

Some compounding pharmacies assign beyond-use dates up to 90 days, but 28 days is the conservative guideline for maximum potency

These findings contribute novel clinical data to the existing literature, which has largely inferred reproductive benefits from improvements in insulin sensitivity, androgen levels, and ovulatory cyclicity [14, 15]

When in doubt, discard and reconstitute a fresh vial

Practical solution: reconstitute with less bacteriostatic water to create a smaller total volume, or accept that you will discard unused solution after 28 days and reconstitute a new vial

Research published in the Journal of Peptide Science found that pH was a key factor in semaglutide thermal degradation, with higher degradation rates observed between pH 4.5 and 5.5, near the peptide isoelectric point of pH 5.4