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Symptoms that can be associated with histamine intolerance include depression, anxiety, nervousness, confusion and sleep disorders

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For patients with a diagnosed deficiency, B12 injections may be given daily or weekly during the initial correction phase, then monthly for maintenance

An in-depth mechanistic study has shown that activation of the BDNF signaling pathway significantly increases protein levels of neurexin- and neuroligin 1 and synaptic plasticity in the hippocampus, possibly involving TrkB/PI3k/AKT/mTOR in this process [54]