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"Essential" means your body cannot produce it on its own, so you must get it through your diet or supplementation

PMID: 15565145 Sosne G, Qiu P, Goldstein AL, Wheater M

Additional MS and MS/MS spectra are available in Figures 4B,C and Figure S1

This in vivo 1 H-MRS study demonstrated that ketamine administration is associated with a transient rise in Glx and GABA levels in patients with depression

This Figure shows conversion of glutamine to glutamate by PAG, followed by a process similar to that occurring in the MAS, with the only exception that the glutamate molecule involved does not originate in the cytosol, but from PAG-activated de-amidation of glutamine in the intermembranaceus space of the mitochondrion