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If GLP-1-GIP-Lani ever reaches the clinic, the relevant variants are likely to include rs10305420 in GLP1R (-0.76 kg additional weight loss per allele on GLP-1 monotherapy, per the 23andMe Nature paper from April 8, 2026), variants in GIPR tied to nausea and tolerability, and possibly variants in PPARG and PPARD that affect nuclear receptor signaling

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Phenytoin doses were subsequently withheld and after 24 h the patient was alert, with no clinical signs or symptoms of phenytoin toxicity or seizure activity

Annie Moore, an internal medicine physician at the CU Anschutz School of Medicine

Almohanna, H.M., Ahmed, A.A., Tsatalis, J.P