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The authors established FOXO4-DRI as a first-in-class senolytic peptide tool for cellular senescence research, with mechanistic selectivity grounded in the elevated FOXO4-p53 interaction in senescent versus non-senescent cells

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Cancer treatments, including chemotherapy and radiation therapy, often exert detrimental effects on the gastrointestinal tract, leading to mucosal damage (mucositis), compromised barrier function, and intestinal inflammation [76]