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The findings of the study indicated that, while metformin was effective in improving biochemical hyperandrogenemia, it did not significantly enhance the sensitivity of the hypothalamus to P4 inhibition (Lundgren et al., 2018)

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However, other studies give us different numbers entirely

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Collectively, these studies highlight the critical importance of brain-resident adaptive immune cells, particularly T cells, and their cytokine signals in CNS homeostasis, neuronal function, and cognitive and behavioral regulation