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The hormone stimulates glucose-dependent insulin secretion from pancreatic beta cells, meaning insulin release occurs only when blood glucose levels are elevated

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Emerging clinical evidence, such as the STEP-HFpEF and FLOW trials, underscores the efficacy of GLP-1RAs in alleviating symptoms, improving quality of life, and slowing disease progression in HFpEF patients

Analogously, the cholinergic neuronal populations have displayed a rhythm with maximal expression of acetylcholine during the active period (Kametani and Kawamura, 1991