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TB-500 also demonstrates potent anti-inflammatory properties by modulating the nuclear factor-kappa B (NF-B) pathway, reducing the production of pro-inflammatory cytokines
Maintaining conditioning during recovery means faster return to full competitive readiness once the injury heals
its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin
Pain Modulation: DSIP is hypothesized to have analgesic-like properties, possibly by influencing opioid receptor activity and modulating pain signal transmission pathways
The peptide modulates nitric oxide synthesis, which governs vascular tone, blood flow, and inflammatory responses across gut, muscle, and neural tissue
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