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AOD9604 and Cartilage Biology Research In a collagenase-induced knee osteoarthritis rabbit model, intra-articular injection of AOD9604 significantly enhanced cartilage regeneration compared to saline controls, with combined AOD9604 and hyaluronic acid injections proving more effective than either treatment alone producing superior morphological and histopathological scores and a significantly shorter lameness period in the AOD9604 + HA group

It plays an important role in brain function, DNA synthesis, and red blood cell production

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It is widely used in biochemical research as a selective, substrate-competitive inhibitor of nicotinamide N-methyltransferase (NNMT)