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NO has a very short half-life in tissues (310 seconds) because it reacts with oxygen and superoxide and then is converted into nitrates and nitrites including peroxynitrite (O=NOO), a reactive nitrogen species (RNS)

The tradeoff is convenience measuring powder is less portable than taking a capsule, and some people may find NAC's sulfur-like taste unpleasant

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57, 48, and 158%, respectively) higher in TMX-treated rats, while HDL-C was significantly lower (Fig