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Higher doses (2000 mg/day) likely saturate hepatic OCTN2 transporters and elevate intracellular carnitine sufficiently to activate CPT1-mediated fatty acid oxidation

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: a randomized, double-blind, placebo-controlled, multicenter trial: the MASTERS trial

It should be avoided if you have a bleeding disorder or are taking anticoagulant/antiplatelet medications (like warfarin or aspirin) as it increases the risk of bruising and bleeding

Some people may also experience a temporary resurgence of symptoms each time their dosage increases

10.3390/pharmaceutics14071313 446 TaniguchiK.SawamuraH.IkedaY.TsujiA.KitagishiY.MatsudaS