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177 Recent studies have found that the interactions between gut microbiota and their metabolites, especially TMAO, and autophagy not only regulate intestinal epithelial function and gut homeostasis but also play a role in regulating physiological functions in distant organs

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We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]

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