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Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation

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[73] demonstrated that MK8722 activates the upstream autophagy pathway PI3K/Akt/mTOR, downregulating FASN expression in a dose-dependent manner, and inhibits downstream autophagy by blocking the fusion of autophagosomes and lysosomes, leading to epithelial ovarian cancer cell death