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BPC-157 has a short plasma half-life (on the order of minutes intravenously ) but its systemic effect exceeds pharmacokinetics, the mechanism acts via signalling cascades and transcription factors

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[2] Several postmarketing reports of pancreatitis (some fatal) have been made in people treated with sitagliptin and other DPP-4 inhibitors, [23] [24] and the US FDA package insert carries a warning to this effect, [2] although the causal link between sitagliptin and pancreatitis has not yet been fully substantiated