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IGF-1R is linked to various cytoplasmic second messenger molecules including the RAS-MAPK and PI3K signalling networks

Additionally, insulin has anabolic effects on muscle by inhibiting proteolysis and promoting protein synthesis

Leave-one-out cross-validation was performed for estimating model accuracy by using caret R package [51]

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Trimethyllysine Hydroxylase (TMLH) The biosynthetic pathway begins with the methylation of lysine residues in proteins to form N6-trimethyllysine (TML)