Second, because GLP-1 drugs often need to be taken for the rest of your life in order to maintain your weight loss results
According to FDA labeling, injectable semaglutide offers some flexibility in dosing
In addition, incretin enthusiasts had suffered a serious disappointment, when it was observed, at about the same time, that GIP although being potently insulinotropic in healthy individuals was ineffective in patients with type 2 diabetes ( not including secretin) also was a potent inhibitor of glucagon secretion ( Inspired by the similarity of GLP-1 with glucagon and oxyntomodulin, it was relevant to look at other glucagon-like gastro-intestinal actions of GLP-1, and via extensive human studies it was soon established that GLP-1 was a physiological and powerful inhibitor of gastrointestinal secretion (both gastric and pancreatic) and motility (65), with a very strong inhibitory effect on gastric emptying (66)
Patients frequently report sustained appetite control, reduced food cravings, and improved energy levels within 2-4 weeks of starting therapy
It should also not be used by those younger than 18 years of age
