Likewise, several in vitro studies have recently suggested a hepatotoxic effect of TVX without LPS using different liver models 24,25,27,39 revealing direct KC activation by TVX and the involvement of intrinsic toxicity mechanisms
This work builds on our previous research, which illustrated that active glutamate uptake through solute carrier family 1 member 1 (EAAT3/SLC1A1) plays a pivotal role in driving cystine uptake via X c for GSH biosynthesis in lung tumorigenesis [19]
Vallano A, Fernandez-Duenas V, Pedros C, Arnau JM, Ciruela F
EA and its analogs EA represents the first clinical application of GST inhibitors
What fewer people understand is just how dramatically the use of these medications has changed in a very short period of time, and what that surge means for patients trying to access them