Retatrutide is an investigational multi-receptor peptide that is not FDA-approved to diagnose, treat, cure, or prevent any disease
Researchers at the University of Texas Medical Branch first characterized 5-amino-1mq in 2017 while searching for ways to inhibit NNMT, an enzyme they had identified as a key regulator of fat cell metabolism
CLINICAL TRIAL EVIDENCE FOR GLP-1 RAs IN MASH Table 2 provides a summary of phase 2 and phase 3 studies examining GLP-1 RAs and dual or triple agonists (aiming glucagon, GIP, and GLP-1 receptors) in individuals with MASLD/MASH, where hepatic biopsies were used to evaluate liver outcomes [3,5,10,11,15,22-25,44-52]
However, the hormonal optimization effects are not permanent without continued use
Though notably, bread consumed with any kind of fat (be it from butter or even cheese) raises GLP-1 more than bread alone