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In the case of chronic hyponatremia, treatment is variable: when sodium is 120129 mEq/L and the patient is mildly symptomatic or asymptomatic, it is sufficient to discontinue any drugs potentially causing hyponatremia, manage the underlying cause of low sodium, and limit oral or intravenous intake of water
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Hence, the application of nanotechnology could enhance the efficacy and improve their bioavailability by increasing solubility, enhancing plasma half-life, preventing degradation in the intestinal environment, and elevating permeation in the small intestine (Hu et al., 2017)
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