Because longterm human studies are lacking, there are concerns about unknown immune, cardiovascular, or proliferative effects, and some experts warn that users may face unpredictable risks, especially with unsupervised use
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And no wonder
Affordable A cost-effective alternative to brand-name medications, making long-term use accessible
Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF, Goodyear LJ, Tian R (2003) Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase