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Mechanisms of gene regulation in human embryos and pluripotent stem cells

Pharmaceutical companies have invested hundreds of millions of dollars in developing disease-modifying drugs, including monoclonal antibodies, inhibitors (e.g., aducanumab, donanemab, donepezil, memantine), while neurologists, psychiatrists, foundations, families, and affected individuals continue to await a transformative therapeutic breakthrough (Knopman et al., 2021)

Diabetes 56, 394403 10.2337/db06-0823 [DOI] [PubMed] [Google Scholar] 83.McCarthy, A.M., Spisak, K.O., Brozinick, J.T

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Lower concentrations (more water) give better precision at low doses but require larger injection volumes at high doses