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Mechanisms of Action and Therapeutic Rationale Physiological Basis of GLP-1 Action GLP-1, an incretin hormone, plays a crucial role in glucose metabolism and appetite regulation, influencing insulin secretion, insulin-sensitivity, and gastric emptying [15] [16]

The abdomen (excluding a 5 cm radius around the navel) offers the most consistent absorption and largest surface area for rotation

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The weight loss timeline for semaglutide shows that most people resume losing weight once they reach therapeutic doses, typically by weeks 8 to 12