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The constructed pURA3-GSH1 strain was heterozygous at the GSH1 locus, with one allele expressing the URA3 ORF under pGSH1 control and the other expressing GSH1 under pTEF1 control (FigureS1 A )

However, genetic factors and baseline metabolism affect the timeline

Month 4 Patients experienced a significant improvement in HbA1c level (reduction of 1.2%) from the baseline (8.28%), and fasting blood glucose level decreased further to 6.4 mmol/L from the baseline (9.6 mmol/L)

At first, Chinese pharmaceutical companies rushed to make similar versions of blockbuster weight-loss drugs, such as Wegovy and Ozempic, that have taken the world by storm