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the degradation rate of drug was determined by measuring the decrease in area under curve (AUC) at the retention time of drug over time

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However, in our opinion, the authors have not always provided clear evidence of direct or mediated Nrf2 involvement in the upregulation in certain systems

Additionally, macrophages in chronic wounds often fail to switch from a pro-inflammatory phenotype to a pro-healing phenotype, resulting in a feed-forward loop of inflammation that prevents resolution