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Production of pro angiogenic factors such as PIGF and VEGFZ and reactive oxidative species also plays a role in endothelial disruption ( A study conducted on rat model demonstrated that liraglutide effectively reduced the mean arterial pressure, a cardinal feature for preeclampsia, leading to decreased blood urea nitrogen (BUN) and creatinine via renal vasodilation

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2004Nov;1033:1-16.doi: 10.1196/annals.1320.001

Sample size calculations were based on phase 2 trial data, which predicted a treatment difference of 1.0 in the Female Sexual Function Index-desire domain (FSFI-D) score and about 20.43 points in the Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO) item 13, with a total of 450 evaluable patients providing sufficient statistical power to detect significant differences